Computational Drug Repurposing

Single-cell genomics.
Novel therapeutics.
43 patented pipelines.

Ritschel Research applies a standardized scRNA-seq pipeline to publicly available human tissue datasets, identifying novel drug-target candidate pairs at single-cell resolution across autoimmune disease, neurodegeneration, oncology, and fibrosis.

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43
Provisional USPTO
Patents Filed 2026
12
Therapeutic
Areas Covered
20+
Independent Pipelines
for WZ-3105
739
Top Compound Score
FTD Pipeline (73 targets)
Portfolio Coverage

12 therapeutic areas. One reproducible pipeline.

18

Autoimmune & Inflammatory

SLE · RA · IBD · MS · Sjögren's · Psoriasis · AD · CREST subtypes

5

Neurodegeneration

Alzheimer's · Parkinson's · ALS · Huntington's · FTD

4

Pulmonary & Fibrotic

Scleroderma · IPF · COPD · Asthma

6

GI & Metabolic

MASH · T1D · T2D · Endometriosis · EoE · IBD

2

Oncology

Glioblastoma · Gastric Premalignant

8

Additional Indications

Long COVID · CKD · Migraine · Sarcoidosis · Inflammaging

Pan-Disease Signal

Three compounds. Twenty-plus independent pipelines. One convergent signal.

WZ-3105
SRC / ABL Inhibitor
Top novel candidate across 20+ independent disease pipelines spanning autoimmune, fibrotic, and neurological indications. Not tuned — emergent from unrelated human tissue datasets.
CHEMBL5653589
Pan-Disease Lead
#1 novel compound across 11 independent pipelines. Top score 739.2 in frontotemporal dementia (73 targets — portfolio record). Also top in Sarcoidosis, EoE, Huntington's, and ALS.
QL-XII-47
MELK / FLT3 Inhibitor
Top novel candidate in IBD (score 2034.6 — portfolio record), irAE (1117.7), GBM, Psoriasis, and T1D. Six or more independent pipelines confirm the signal.
Methodology

Standardized. Reproducible. Fully archived.

01
scRNA-seq Input
NCBI GEO public
datasets
02
scVI Batch Correction
GPU-accelerated
integration
03
Leiden Clustering
Cell-type-specific
resolution
04
Wilcoxon DE
Top DE genes
per cluster
05
ChEMBL Screen
pChEMBL ≥7.5
bioactivity filter
06
Novelty Filter
PubChem patent
classification
07
Ranked Output
Scored candidates
+ watchlist

All 43 patent specifications and companion preprints archived on Zenodo (CC BY 4.0) with permanent DOIs. All GEO datasets publicly available and independently reproducible. Sole inventor: Glen Charles Ritschel. Priority dates: February–April 2026.

Licensing & Partnership

Seeking option or license agreement with buyer-funded non-provisional conversion.

Full portfolio exclusivity, therapeutic-area carve-outs, and pan-disease compound package structures are all available. Priority dates expire February–April 2027. One coordinated diligence cycle covers all 43 patents simultaneously — the Zenodo archive is your data room, available now.
Inventor
Glen Charles Ritschel
Organization
Ritschel Research, Tega Cay SC
Email
[email protected]
Archive
zenodo.org — search "Ritschel Research"
Code
github.com/glenritschel

Request received — Glen will respond within one business day.
Data room: zenodo.org → search "Ritschel Research"